Genica Genetic Tests for Mental Health
Mental Health

Genetic Tests for Mental Health

Almost 1 in 5 people suffer from mental illnesses and a large proportion of the affected receive trial-and-error treatment. Our mission is to improve the quality of life for people with mental illness by using genetic technology to create personalized treatment plans.

Depression, anxiety, hyperactivity, obsessive-compulsive disorder, bipolar disorder, schizophrenia, and personality disorders are among the psychiatric conditions that can be positively influenced with adequate therapy based on results from genetic testing.

The GENICA’s Mental Health Genetic Test analyzes how patients’ genes can affect their response to certain medicines. The test result provides the doctor with information about which drugs are most effective and least toxic for the patient, as well the dose needed.

Personalized Drug Therapy

Antipsychotic

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Typical and atypical antipsychotic

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 1,030

Clinical application

Determining the appropriate dose for upcoming therapy

Personalized Drug Therapy

Antidepressants

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Antidepressants - SSRI, SNRI, tricyclic, tetracyclic and others

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 790

Clinical application

Determining the appropriate dose for upcoming therapy

Identification of All Bacterial Species in the Intestinal Tract

Microbiome MINI

Microbiome MINI involves molecular genetic diagnosis to identify all bacterial species inhabiting the intestinal tract. It covers over 250 parameters, used to determine biodiversity, condition and permeability of the intestinal mucosa, the formation of functional groups (equol, butyrate, histamine, hydrogen sulfide), parasites presence. Valuable information about a person's health and lifestyle can be obtained depending on the microbiome condition. 

Diagnostic Range: Feces condition; Biodiversity; Distribution of bacterial genera; Enterotype; Dysbiosis index; Most important bacterial genera and species: Bacteriodetes, Firmicutes, Actinobacteria, Proteobacteria (pathogenic or potentially pathogenic), Verrucomicrobia, Clostridia, Immunologically effective species, Yeast / Fungi and other forming functional groups (equol, butyrate, histamine, hydrogen sulfide).

Diagnostic Method: New generation sequencing and DNA quantification

Research Material: Feces

Results within: 15-20 business days

Fee: BGN 378

Clinical application

 Metabolic disorders; Intestinal inflammation (Crohn's disease); Intestinal tumors; Autism; Alzheimer's; Arthritis; Obesity 

Pharmacogenetic Panel Antidepressants, Antipsychotics and Mood Stabilizers

Mental Health (Main Panel)

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Antidepressants - SSRI, SNRI, tricyclic, tetracyclic and others; Antixiolytics; Typical and atypical antipsychotic; Mood stabilizers

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous Blood

Results within: 10 business days

Fee: BGN 1,170

Clinical application

 Determining the appropriate dose for upcoming therapy 

Personalized Drug Therapy

Metabolism of Dopamine, Serotonin, and Folate

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Cerebral neurotransmitter - metabolism of dopamine, serotonin and folate; Antidepressants - SSRI, SNRI, tricyclic, tetracyclic and others; Antixiolytics; Typical and atypical antipsychotic; Mood stabilizers

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 410

Clinical application

Determining the appropriate dose for upcoming therapy

Pharmacogenetic Panel Antidepressants, Antipsychotics, and Mood Stabilizers

Mental Health (Full Panel)

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Mental health (full panel) includes all the tests in Mental health (main panel) + Brain neurotransmission - metabolism of dopamine, serotonin, and folate.

Diagnostic range: Cerebral neurotransmitter - metabolism of dopamine, serotonin and folate; Antidepressants - SSRI, SNRI, tricyclic, tetracyclic and others; Antixiolytics; Typical and atypical antipsychotic; Mood stabilizers

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 1,320

Clinical application

Determining the appropriate dose for upcoming therapy

Personalized Drug Therapy

Mood Stabilizers

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Antixiolytics; Mood stabilizers

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 850

Clinical application

Determining the appropriate dose for upcoming therapy

Determination of Bacterial Species and Parasites in the Intestinal Tract

Microbiome MIDI

The Microbiome MIDI genetic panel is an extension of Microbiome MINI panel and additional types of parasites (Giardia lamblia, Entamoeba histolytica, etc.) are included.

Diagnostic Range: Feces condition; Biodiversity; Distribution of bacterial genera; Enterotype; Dysbiosis index; Most important bacterial genera and species: Bacteriodetes, Firmicutes, Actinobacteria, Proteobacteria (pathogenic or potentially pathogenic), Verrucomicrobia, Clostridia, Immunologically effective species, Yeast / Fungi and other forming functional groups (equol, butyrate, histamine, hydrogen sulfide); Additional types of parasites.

Diagnostic Method: New generation sequencing and DNA quantification

Research Material: Feces

Results within: 15-20 business days

Fee: BGN 459

Clinical application

 Metabolic disorders; Intestinal inflammation (Crohn's disease); Intestinal tumors; Autism; Alzheimer's; Arthritis; Obesity 

Determination of Bacterial Species and Parasites in the Intestinal Tract

Microbiome MAXI

The Microbiome MAXI genetic panel is an extension of Microbiome MIDI panel and additional species of the genera Actinobacteria and Clostridia; Hydrogen sulfide producing bacteria and Oxalate - degrading bacteria are included.

Diagnostic Range: Feces condition; Biodiversity; Distribution of bacterial genera; Enterotype; Dysbiosis index; Most important bacterial genera and species: Bacteriodetes, Firmicutes, Actinobacteria, Proteobacteria (pathogenic or potentially pathogenic), Verrucomicrobia, Clostridia, Immunologically effective species, Yeast / Fungi, and other forming functional groups (equol, butyrate, histamine, hydrogen sulfide); Additional types of parasites; Additional species of Actinobacteria, Clostridia; Additional species of hydrogen sulfide-producing bacteria; Oxalate - degrading bacteria

Diagnostic Method: New generation sequencing and DNA quantification

Research Material: Feces

Results within: 15-20 business days

Fee: BGN 507

Clinical application

Metabolic disorders; Intestinal inflammation (Crohn's disease); Intestinal tumors; Autism; Alzheimer's; Arthritis; Obesity

Vitamins Absorption

Vitamins

Vitamins play a key role in the proper performance of basic functions of the human body such as metabolism, immune defense, activity of the central and peripheral nervous systems, digestion, movement etc. Most vitamins are not synthesized in the human body but are taken with food as precursors of their active forms. Therefore, their proper absorption, transformation, use, and decomposition is important for maintaining the so-called vitamin balance.

The Vitamins Genetics Panel includes an analysis of genetic variants associated with predisposition to vitamin A, B, D, and K deficiencies. The results contain interpretation, clinical significance of proven variants, and recommendations that assist practitioners in making therapeutic decisions. Each patient receives guidelines for changing their diet, as well as for taking specific vitamins and minerals.

Diagnostic Range: Absorption of vitamins A, B2, B6, B9 (folic acid), B12, D and K.

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: 3-6 ml venous blood / 2 ml peripheral blood

Results within: 10 business days

Fee: BGN 710

Clinical application

Eating disorders; Metabolic disorders

Impaired Vitamin B6 Absorption

Vitamin B6

Vitamin B6 is an important factor in the formation of the red blood cells, the developing of nervous tissue, the detoxification processes, the DNA synthesis, the cell energy balance and the immune protection. It is also a key factor in the methylation processes that regulate the "unlocking" or "locking" of our genes. Methylation disorders can lead to elevated homocysteine levels, which are associated with a large number of diseases.

Vitamin B6 Genetic Panel includes analysis of genetic variants associated with faster degradation of vitamin B6 and systemically low bioavailability of its active form, called Pyridoxal-5-phosphate. The results contain interpretation, clinical significance of identified variants and recommendations to assist specialists in making therapeutic decisions.

Diagnostic Range: Genetic variants associated with deficiency and faster degradation of Vitamin B6

Diagnostic Method: Sanger sequencing

Research Material: 3-6 ml venous blood / 2 ml peripheral blood

Results within: 10 business days

Fee: BGN 150

Clinical application

Metabolic disorders; Eating disorders

Predisposition to Vitamin B12 Deficiency

Vitamin B12

Vitamin B12 is supplied only with food. It is a key factor in to the functioning of vital body processes, including the formation of red blood cells, DNA synthesis, normal nervous system function, digestion. If Vitamin B12 deficiency is not managed in time, it can lead to anemia, a number of gastrointestinal, neurological, oncological, and other diseases.

Vitamin B12 Genetic Panel includes analysis of genetic variants associated with disorders in the absorption of the vitamin in the small intestine, reduced transport to the liver and faster depletion of its active form.

The results contain interpretation, clinical significance of identified variants and recommendations to assist specialists in making therapeutic decisions.

Diagnostic Range: Absorption, transport and use of vitamin B12 in the body.

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: 3-6 ml venous blood / 2 ml peripheral blood

Results within: 10 business days

Fee: BGN 280

Clinical application

Neurology; Hematology; Endocrinology; Gastroenterology; Psychiatry Anemia

Impaired Histamine Degradation

Histamine Intolerance

A wide range of foods are naturally rich in histamine or release high levels of histamine during storage. Diamine oxidase (DAO) is an intestinal enzyme that normally destroys histamine contained in food. Therefore, even after consuming foods rich in histamine, no symptoms are observed. In carriers of genetic variants, DAO deficiency is observed, and undigested histamine is unnecessarily absorbed, exhibiting various symptoms.

Gastrointestinal symptoms: diarrhea, irritable bowel syndrome (IBS), chronic constipation, gas, stomach pain, vomiting.

Symptoms affecting the head and face: redness of the face and / or chest (a very common symptom), migraine-like headache, Quincke's edema (swelling that occurs mainly around the eyes and lips, sometimes in the throat).

Respiratory problems: asthma, stuffy nose and watery eyes.

Skin complaints: rash, eczema, urticaria, acne.

In women: dysmenorrhea. The symptoms of HIT disappear during pregnancy and return after birth.

Other symptoms: wheezing, sleep disorders, arrhythmia, mood swings - from fatigue to irritability and aggression.

Diagnostic Range: DAO; HNMT

Diagnostic Method: Sanger sequencing

Research Material: 3-6 ml venous blood / 2 ml peripheral blood

Results within: 10 business days

Fee: BGN 200

Clinical application

Histamine intolerance