Genica Genetics of Cancer
Oncology

Genetics of Cancer

Genetic testing for hereditary and somatic cancers is the basis for proper diagnosis and treatment of affected patients. It can help families better understand their risk of cancer and to decide if they should get tested or learn about how to lower their risk of cancer. Genetic testing helps detecting cancer earlier when treatment is most likely to work better.

Some families may be at increased risk of developing certain types of cancer due to inherited gene mutations. Genetic analysis can determine if you are at increased risk of developing cancer and suggest an appropriate strategy for prevention or monitoring.

Thanks to genetic tests, doctors can choose the right therapeutic options. Some cancers, for example, will respond differently to treatment by particular classes of drugs, depending on the presence or absence of certain genetic variants. Testing and treating tumors in such a way is also known as personalized medicine.

GENICA tests a wide range of genetic variants, enabling early prevention, cancer diagnosis, prognosis, treatment choice and post-therapeutic monitoring of the patient. Our set of oncological tests is extensive and is continuously updated. Contact us if you cannot find a specific test you need.

Genetic Tests for Cancer Detection and Prevention

Hereditary Cancer Panel – Women

This test detects mutations in 74 genes associated with 23 different types of cancer in women, including breast cancer, ovarian cancer, colorectal cancer, endometrial cancer, gastric cancer, kidney cancer, thyroid cancer, parathyroid cancer, multiple endocrine adenomas, neurofibromatosis, pheochromocytosis, bladder cancer, ureteral cancer, familial paraganglioma, retinoblastoma, melanoma, multiple osteochondroma, gastrointestinal tumors, hereditary neuroblastoma, tuberous sclerosis, hereditary nephroblastoma. 

Genetic testing for hereditary and somatic cancers is the basis for proper diagnosis and treatment in affected patients. They are also indispensable in the early prevention of their relatives, who are carriers of genetic mutations associated with the risk of developing cancer. We can guide doctors in choosing the right therapeutic options with the help of genetic tests for detecting and preventing cancer.

GENICA Lab analyses a wide range of genetic variants, enabling early prevention, cancer diagnosis, prognosis, treatment choice and post-therapeutic monitoring of the patient.

Diagnostic Range: ALK, APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK12, CDK4, CDKN1B, CDKN2A, CHEK2, EPCAM, EXT1, EXT2, FANCG, FH, FLCN, GALNT12, KIT, MAX, MEN1, MET, MLH1, MLH3, MRE11A, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, NTRK1, PALB2, PDGFRA, PHOX2B, PMS1, PMS2, POLD1, POLE, PRSS1, PTCH1, PTCH2, PTEN, RAD50, RAD51C, RAD51D, RB1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SPINK1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, WT1, XPC

Diagnostic Method: Next-Generation Sequencing

Research Material: Venous blood

Results within: 20 business days

Fee: BGN 1,400

Clinical application

 Hereditary carcinoma 

Genetic Tests for Cancer Detection and Prevention

Hereditary Cancer Panel - Men

The test detects mutations in 79 genes associated with 23 different types of cancer in men, including breast cancer, colorectal cancer, prostate cancer, stomach cancer, kidney cancer, thyroid cancer, parathyroid cancer, multiple endocrine adenomas, neurofibromatosis, pheochromocytosis, bladder cancer, ureteral cancer, familial paraganglioma, retinoblastoma, melanoma, multiple osteochondroma, gastrointestinal tumors, hereditary neuroblastoma, tuberous sclerosis, hereditary nephroblastoma. 

Genetic testing for hereditary and somatic cancers is the basis for proper diagnosis and treatment in affected patients. They are also indispensable in the early prevention of their relatives, who are carriers of genetic mutations associated with the risk of developing cancer. We can guide doctors in choosing the right therapeutic options with the help of genetic tests for detecting and preventing cancer.

GENICA Lab analyses a wide range of genetic variants, enabling early prevention, cancer diagnosis, prognosis, treatment choice and post-therapeutic monitoring of the patient.

Diagnostic Range: ALK, APC, ATM, ATR, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK12, CDK4, CDKN1B, CDKN2A, CHEK2 ,EPCAM, EXT1, EXT2, FAM175A, FANCA, FANCG, FH, FLCN, GALNT12, GEN1, HOXB13, KIT, MAX, MEN1, MET, MLH1, MLH3, MRE11A, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, NTRK1, PALB2, PDGFRA, PHOX2B, PMS1, PMS2, POLD1, POLE, PRSS1, PTCH1, PTCH2, PTEN, RAD50, RAD51C, RAD51D, RB1, RET, SDHA,

Diagnostic Method: Next-Generation Sequencing

Research Material: Venous blood

Results within: 20 business days

Fee: BGN 1,400

Clinical application

 Hereditary carcinoma 

Sexually Transmitted Infections Associated with the Risk of Cancer

Cervical Cancer

 Cervical cancer is the second most common cancer globally among women between the ages of 20 and 55. It is caused by the human papillomavirus (HPV). Cervical cancer is the final stage of untreated HPV infection, characterized by the continuing presence of HPV and detected by repeated DNA testing of cervical samples. HPV infection is primarily sexually transmitted and usually occurs without clinical signs or symptoms.

The process from HPV infection to cancer is slow. This makes the initiating infections and the pre-disease lesions treatable with regular prophylaxis, thus preventing the development of cervical cancer.

Up to 93% of cervical cancers are preventable with GENICA’s diagnostic solutions. READ MORE

Diagnostic Range: HPV from 12 to 33 types

Diagnostic Method: PCR Assay

Research Material: Cervical specimen

Results within: 1-5 business days

Fee: BGN 66 - BGN 167 depending on the test selected

Clinical application

Cervical dysplasia; Cervical cancer; Oral cancer; Cancer of the vulva and vagina; Penile cancer; Anal cancer; Genital warts 

Download Our Brochure

Download Our Brochure

BRCA1 / BRCA2 Panel

Hereditary breast cancer and ovarian cancer - 26 genes

This test detects mutations in 26 genes associated with breast cancer and ovarian cancer.

Diagnostic Range: BRCA1, BRCA2, CHEK2, PALB2, BRIP1, TP53, PTEN, STK11, CDH1, ATM, BARD1, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, RAD50, RAD51C, RAD51D, NF1, EPCAM, SMARCA4, CDK12

Diagnostic Method: NGS

Research Material: Venous blood

Results within: 20 business days

Fee: BGN 1,200

Clinical application

Breast Cancer

Cancerous Diseases

Gynecologic Oncology

A group of DNA tests associated with gynecologic cancers, including cervical cancer (SEE MORE), endometrial cancer, ovarian cancer, breast cancer.

Diagnostic Range: Human papillomavirus (HPV) associated with cervical cancer; MLH1, MSH2, MSH6, PMS2, EPCAM, STK11, TP53, PTEN, MUTYH associated with hereditary endometrial carcinoma; BRCA1, BRCA2, CHEK2, PALB2, BRIP1, TP53, PTEN, STK11, CDH1, ATM, BARD1, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, RAD50, RAD51C, RAD51D, NF1, EPCAM, SMAR HOXB13 associated with ovarian and breast cancer

Diagnostic Method: Genetic analysis

Research Material: Cervical specimen / Biopsy material / Venous blood

Results within: 5-20 business days for various analyzes

Fee: From BGN 48 to BGN 1,800 for various analyzes

Clinical application

Cervical cancer; Endometrial cancer; Ovarian cancer; Breast cancer

Download Our Brochure

BRCA1, BRCA2

Hereditary breast cancer and ovarian cancer - 2 genes

This test detects mutations in the two main genes associated with breast cancer and ovarian cancer.

Diagnostic Range: BRCA1, BRCA2

Diagnostic Method: NGS

Research Material: Venous blood

Results within: 20 business days

Fee: BGN 1200

Clinical application

Breast cancer, ovarian cancer

Mutations in the IDH1 / IDH2 Genes

Oncomutations

The pharmacogenetics of cancer identifies patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. 

There are significant differences between the pharmacogenomics of cancer and other diseases.

Diagnostic Range: IDH1/IDH2

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 150

Clinical application

Personalized therapy

Cancerous Diseases

Hereditary pancreatic cancer 12 genes

This test detects mutations in 12 genes associated with pancreatic cancer.

Diagnostic Range: BRCA2, PALB2, BRCA1, MLH1, MSH2, MSH6, PMS2, PRSS1, SPINK1, ATM, CDKN2A, FANCG

Diagnostic Method: NGS

Research Material: Venous blood

Results within: 20 business days

Fee: BGN 1,200

Clinical application

Pancreatic cancer

Genetic Mutations Associated with the Risk of Developing Cancer

Hereditary colon carcinoma (COLORECTAL CANCER) - 23 genes

This test detects mutations in 23 genes associated with colon cancer.

Diagnostic Range: APC, AXIN2, EPCAM, MLH1, MLH3, MSH2, MSH6, MUTYH, PMS1, PMS2, STK11, PTEN, SMAD4, BMPR1A, ATM, BLM, CHEK2, GALNT12, MSH3, NTHL1, POLD1, POLE, TP53

Diagnostic Method: NGS

Research Material: Venous blood

Results within: 20 business days

Fee: BGN 1,200

Clinical application

Colon cancer

Genetic Mutations Associated with the Risk of Developing Cancer

Hereditary prostate carcinoma (PROSTATE CANCER) - 23 genes

This test detects mutations in 23 genes associated with prostate cancer.

Diagnostic Range: BRCA1, BRCA2, CHEK2, HOXB13, MSH2, MSH6, PMS2, MLH1, ATM, BRIP1, PALB2, MRE11A, NBN, RAD51C, RAD51D, ATR, FAM175A, GEN1, MUTYH, TP53, EPCAM, FANCA, CDK12

Diagnostic Method: NGS

Research Material: Venous Blood

Results within: 20 business days

Fee: BGN 1,200

Clinical application

Prostate cancer

Hypermethylation of the MGMT Promoter Region

MGMT Hypermethylation

The pharmacogenetics of cancer identifies patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. There are significant differences between the pharmacogenomics of cancer and other diseases.

Diagnostic Range: Hypermethylation of the MGMT promoter region

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 270

Clinical application

Personalized therapy

Next-Generation Sequencing

Next-Generation sequencing (NGS)/ Whole Exome Sequencing (WES)

 This test detects mutations in 20,000 genes associated with various hereditary conditions. It analyzes packages of target genes associated with specific conditions according to clinical diagnosis (Cancer Panel, Pediatric Panel, Diabetes Panel, Epilepsy Panel, Intellectual Deficiency/Autism Panel, Skeletal Dysplasias Panel, Cardiomyopathies Panel, etc.). 

Diagnostic Range: ~20 000 genes

Diagnostic Method: Next-Generation Sequencing

Research Material: Venous blood

Results within: 2 to 4 months

Fee: BGN 3800

Clinical application

Cancer, childhood diseases, diabetes, epilepsy, intellectual deficit/autism, skeletal dysplasia, cardiomyopathies, etc. 

Cancerous Diseases

Multiple endocrine neoplasia - MEN1

This test detects mutations in the MEN1 gene associated with MEN1 multiple endocrine neoplasia.

Diagnostic Range: MEN1

Diagnostic Method: Sanger sequencing/MLPA

Research Material: Venous blood

Results within: 10 business days

Fee: Sanger - BGN 1100 BGN / MLPA - BGN 800

Clinical application

Multiple endocrine neoplasia

Cancerous Diseases

Multiple endocrine neoplasia - MEN2

This test detects mutations in the RET gene associated with MEN2 multiple endocrine neoplasia.

Diagnostic Range: RET

Diagnostic Method: Sanger sequencing/MLPA

Research Material: Venous blood

Results within: 10 business days

Fee: Sanger - BGN 2400 / MLPA - BGN 800

Clinical application

Multiple endocrine neoplasia

Cancerous Diseases

Von Hipple-Lindau syndrome

This test detects mutations in the VHL gene associated with von Hipple-Lindau syndrome.

Diagnostic Range: VHL

Diagnostic Method: Sanger sequencing/MLPA

Research Material: Venous blood

Results within: 10 business days

Fee: Sanger - BGN 600 / MLPA - BGN 800

Clinical application

Von Hipple-Lindau syndrome