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Pharmacogenetics

The Right Medicine for You

Pharmacogenetics aims to determine the most appropriate drug treatment for a person. It examines how the DNA affects the way one responds to drugs.

Pharmacogenetic tests seek for genetic variants that are associated with a variable response to specific drugs. These variants are found in genes that encode enzymes metabolizing the drug, drug targets, or proteins involved in the immune response.

Severe drug reactions cause more than 120,000 hospitalizations each year. Pharmacogenetics can prevent this by identifying patients at risk and providing information on the correct drug dose.

Personalized Drug Therapy

Antipsychotic

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Typical and atypical antipsychotic

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 1,030

Clinical application

Determining the appropriate dose for upcoming therapy

Loss of Heterozygosity in 1p / 19q Regions + Mutations in IDH1 / 2

Oncopharmacology Main Panel

The pharmacogenetics of cancer identifies patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. There are significant differences between the pharmacogenomics of cancer and other diseases.

Diagnostic Range: 1p/19q/IDH1/2

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 500

Clinical application

Personal therapy 

Personalized Drug Therapy

Antidepressants

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Antidepressants - SSRI, SNRI, tricyclic, tetracyclic and others

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 790

Clinical application

Determining the appropriate dose for upcoming therapy

Pharmacogenetic Panel Antidepressants, Antipsychotics and Mood Stabilizers

Mental Health (Main Panel)

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Antidepressants - SSRI, SNRI, tricyclic, tetracyclic and others; Antixiolytics; Typical and atypical antipsychotic; Mood stabilizers

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous Blood

Results within: 10 business days

Fee: BGN 1,170

Clinical application

 Determining the appropriate dose for upcoming therapy 

Personalized Drug Therapy

Metabolism of Dopamine, Serotonin, and Folate

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Cerebral neurotransmitter - metabolism of dopamine, serotonin and folate; Antidepressants - SSRI, SNRI, tricyclic, tetracyclic and others; Antixiolytics; Typical and atypical antipsychotic; Mood stabilizers

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 410

Clinical application

Determining the appropriate dose for upcoming therapy

Personalized Drug Therapy

Mood Stabilizers

The Mental Health Pharmacogenetic Test is a modern diagnostic tool to help determine drug therapy. It examines the individual interaction between a patient's genome and a drug. The test results are a factor in optimizing the dose or in choosing an alternative drug to avoid side effects and to optimize the efficacy of the prescribed therapy. The Mental Health Pharmacogenetic Test is an additional toll to the standard approach when prescribing therapy, which could eliminate the long path of trial-and-error and the unexpected side effects of drug selection and dosing.

Results for patients with the same diagnosis treated in the same way can be different. The same drug can be very effective or ineffective, may have no side effects, or may have many as for each person the genome and the combination of enzymes it produces is unique. 

Diagnostic Range: Antixiolytics; Mood stabilizers

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 850

Clinical application

Determining the appropriate dose for upcoming therapy

Mutations in the IDH1 / IDH2 Genes

Oncomutations

The pharmacogenetics of cancer identifies patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. 

There are significant differences between the pharmacogenomics of cancer and other diseases.

Diagnostic Range: IDH1/IDH2

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 150

Clinical application

Personalized therapy

TPMT

Thiopurine Therapy

The pharmacogenetics of cancer identifies patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. There are significant differences between the pharmacogenomics of cancer and other diseases.

Diagnostic Range: TPMT

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 210

Clinical application

Personalized therapy

Hypermethylation of the MGMT Promoter Region

MGMT Hypermethylation

The pharmacogenetics of cancer identifies patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. There are significant differences between the pharmacogenomics of cancer and other diseases.

Diagnostic Range: Hypermethylation of the MGMT promoter region

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 10 business days

Fee: BGN 270

Clinical application

Personalized therapy

Pharmacogenetic Tests in Cardiology

Clopidogrel Therapy (Plavix)

Pharmacogenetics in cardiology allows the identification of patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. 

Diagnostic Range: CYP2C19

Diagnostic Method: Sanger sequencing

Research Material: Venous blood

Results within: 5-10 business days

Fee: BGN 120

Clinical application

Personalized therapy

Pharmacogenetic Tests in Cardiology CYP2C9 VKORC1

Warfarin Therapy (Sintrom)

The Pharmacogenetics in Cardiology allows identification of patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. There are significant differences between the pharmacogenomics of cancer and other diseases.

Diagnostic Range: CYP2C9, VKORC1

Diagnostic Method: Sanger sequencing/ RFLP

Research Material: Venous blood

Results within: 5-10 business days

Fee: BGN 120

Clinical application

Personalized therapy

Statin Therapy: Simvastatin, Pravastatin, Rosuvastatin

Statin Therapy

The Cardio Pharmacogenetics allows identification of patients at risk of severe toxicity or those who are likely to benefit from a particular treatment. Thus, it helps to design individualized cancer therapy. There are significant differences between the pharmacogenomics of cancer and other diseases.

Diagnostic Range: Statin Therapy: Simvastatin, Pravastatin, Rosuvastatin

Diagnostic Method: Sanger sequencing

Research Material: Venous blood

Results within: 5-10 business days

Fee: BGN 100

Clinical application

Personalized therapy